Predicting Amino Acid Preferences in the Complementarity Determining Regions of an Antibody-Antigen Recognition Interface
Our research team develops antibody therapeutics/diagnostics with the technological platforms developed in our lab. Our technologies, which provide antibody-based solutions to human diseases with short development course at low cost, are based on the phage-displayed GH (Generic Human) synthetic antibody libraries designed and constructed with enabling approaches, leading to the throughput capacities to uplift the innovativeness and productivity in developing antibody therapeutics and diagnostics. In conjunction with the core technologies, antibody bioinformatics capable of extracting knowledge from big data of human antibody repertoires is used to elucidate human antibody responses and to assist antibody library design. We also collaborate with the structural biology groups in Academia Sinica, using x-ray crystallography and cryo-EM for epitope mapping at atomistic details to elucidate the functions and mechanisms of antibody therapeutics.
Yang, An-Suei, Ph. D.
Research Fellow
Web site
Research Areas
1 Antibody bioinformatics and computational antibody designs (抗體生物資訊及抗體序列設計)1-9
2 Antibody discoveries with phage-displayed synthetic antibody libraries (合成人源抗體庫集成建構並運用於抗體藥物開發)1,3,10,11
3 High throughput discovery of antibody-drug conjugate candidates (抗體引導毒素傳送高通量篩選技術)3,10
4 Anibody therapeutics optimization with computation and high throughput screening (抗體藥物優化)11
5 Structure determination of antibody-antigen complex structures for elucidation of epitopes and mechanism of actions for antibody therapeutics (抗體的特定結合區域及藥效相關性)10
Web server
ISMBLabLogo In silico molecular biology laboratory (ISMBLab): predict protein/peptide/carbohydrates/DNA/RNA/small molecules/metal/ion/water binding sites on protein (antibody) structures.Link
Yang, An-Suei Laboratory, Genomics Research Center, Academia Sinica. 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan